IIS 7.5 - Appcmd Script to Relocate INETPUB

A handy script to relocate the INETPUB folder from the C drive:

%windir%\system32\inetsrv\appcmd set config -section:system.applicationHost/sites -siteDefaults.traceFailedRequestsLogging.directory:"E:\Inetpub\logs\FailedReqLogFiles"
%windir%\system32\inetsrv\appcmd set config -section:system.applicationHost/sites -siteDefaults.logfile.directory:"E:\Inetpub\logs\logfiles"
%windir%\system32\inetsrv\appcmd set config -section:system.applicationHost/log -centralBinaryLogFile.directory:"E:\Inetpub\logs\logfiles"
%windir%\system32\inetsrv\appcmd set config -section:system.applicationHost/log -centralW3CLogFile.directory:"E:\Inetpub\logs\logfiles"
reg add HKLM\System\CurrentControlSet\Services\WAS\Parameters /v ConfigIsolationPath /t REG_SZ /d E:\Inetpub\temp\appPools
%windir%\system32\inetsrv\appcmd set config -section:system.applicationhost/configHistory -path:E:\Inetpub\history
%windir%\system32\inetsrv\appcmd set config -section:system.webServer/asp -cache.disktemplateCacheDirectory:"E:\Inetpub\temp\ASP Compiled Templates"
%windir%\system32\inetsrv\appcmd set config -section:system.webServer/httpCompression -directory:"E:\Inetpub\temp\IIS Temporary Compressed Files"
%windir%\system32\inetsrv\appcmd set vdir "Default Web Site/" -physicalPath:E:\Inetpub\wwwroot
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='401'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='403'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='404'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='405'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='406'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='412'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='500'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='501'].prefixLanguageFilePath:E:\Inetpub\custerr
%windir%\system32\inetsrv\appcmd set config -section:httpErrors /[statusCode='502'].prefixLanguageFilePath:E:\Inetpub\custerr
reg add HKLM\Software\Microsoft\inetstp /v PathWWWRoot /t REG_SZ /d E:\Inetpub\wwwroot
reg add HKLM\Software\Microsoft\inetstp /v PathFTPRoot /t REG_SZ /d E:\Inetpub\ftproot
xcopy c:\Inetpub E:\Inetpub /E /O /I
REM Also Enable Compression
%windir%\system32\inetsrv\appcmd set config /section:urlCompression /doDynamicCompression:True
%windir%\system32\inetsrv\appcmd set config /section:urlCompression /doStaticCompression:True

Source: http://blogs.iis.net/thomad/archive/2008/02/10/moving-the-iis7-inetpub-directory-to-a-different-drive.aspx